ABSTRACT
Four patients with shoulder problems that were traumatic in etiology presented to us with delays in seeking care ranging from 6 to 12 weeks due to the coronavirus disease 2019 (COVID-19) lockdown. The care of three cases (a 3-month-old neglected anterior shoulder dislocation with a greater tuberosity fracture in a 30-year old man, a 3-month-old neglected anterior shoulder dislocation in a 17-year old boy, and a 2-month-old neglected greater tuberosity fracture in a 31-year old man) was delayed due to the lockdown and the ensuing travel restrictions, while that of one case (a 6-week-old fracture–dislocation of the proximal humerus in a 55-year-old woman) was delayed because the patient was undergoing treatment for COVID-19 at the time of injury. This report intends to present the exceptional circumstances around these cases. The unique treatment challenges and their outcomes are also described to advise the surgeons of the nuances and difficulties in treating these injuries.
ABSTRACT
Due to the increasing use of preclinical targeted radionuclide therapy (TRT) studies for the development of novel theranosticagents, several studies have been performed to accurately estimate absorbed doses to mice at the voxel level using referencemouse phantoms and Monte Carlo (MC) simulations. Accurate dosimetry is important in preclinical theranostics to interpretradiobiological dose-response relationships and to translate results for clinical use. Direct MC (DMC) simulation is believed toproduce more realistic voxel-level dose distribution with high precision because tissue heterogeneities and nonuniform sourcedistributions in patients or animals are considered. Although MC simulation is considered to be an accurate method for voxelbasedabsorbed dose calculations, it is time-consuming, computationally demanding, and often impractical in daily practice. Inthis review, we focus on the current status of voxel-based dosimetry methods applied in preclinical theranostics and discuss theneed for accurate and fast voxel-based dosimetry methods for pretherapy absorbed dose calculations to optimize the dosecomputation time in preclinical TRT.
ABSTRACT
Colonization with methicillin resistant Staphylococcus aureus [MRSA] is considered to be a major risk factor for skin and soft tissue infections. We present a case of a patient suffering from necrotizing soft tissue infection and exposed to multiple antibiotics and developed colonization with linezolid resistant MRSA [LRMRSA]. He could not be decolonized despite prolonged conventional or modified MRSA decolonization protocols